Relationships | 10/15/2008 10:36 am
Study: Vitamin B Does Not Slow Alzheimer's, May Boost Depression

New research delivers bad news about the so-called brain-boosting powers of vitamin B.
Past research has suggested that vitamin B may sharpen memory and reduce the risk of Alzheimer’s Disease. The belief was that B vitamins could help reduce levels of homocysteine in the blood, which may, in turn, reduce the possibility of developing the mentally debilitating disease, according to Glenn Smith, Ph.D., a Mayo Clinic neuropsychologist.
However, according to a new study published today, while vitamin B did lower homocysteine levels (which are amino acids in the blood), it did not sharpen the brain.
Researchers gave 409 people with mild to moderate Alzheimer’s disease high-dose supplements of vitamins B6, B12 and folate for 18 months. There was also a placebo group that did not receive the vitamin. When the scientists gave both groups cognitive skill exams
to test their memory and language skills, they found that the
B-vitamin group fared no better than the placebo subjects. Thus, they concluded that while vitamin B did lower homocysteine levels, it did not impact the patient’s cognitive deterioration.
"Prior studies using B vitamin supplementation to reduce homocysteine levels in patients with Alzheimer’s weren’t large enough, or of long enough duration to effectively assess their impact on cognitive decline," said Dr. Paul S. Aisen of the University of California, San Diego, in La Jolla, in a press release. "This study of several hundred individuals over the course of 18 months showed no impact on cognition, although it resulted in lower levels of homocysteine in these patients."
And the researchers also discovered something a bit surprising: the people who took the vitamin supplements were more likely to suffer from depression.
Alzheimer’s usually begins after age 60, and risk goes up with age. Scientists believe that as many as 4.5 million Americans suffer from the disease, according to the National Institute on Aging. It usually develops slowly as nerve cells and connections near the brain begin to deteriorate and die affecting memory and mental abilities.
The study was published in the October 15 issue of the Journal of the American Medical Associate. Click here to read more about the study.
Vitamin B Facts:
Folic Acid - Helps the body make healthy new cells. For women, it helps prevent major birth defects. It’s found in leafy green vegetables, peas, dried beans, nuts and certain enriched grains.
B 12 - Helps the body maintain healthy nerve cells and red blood cells. It’s found in fish, shellfish, meat and dairy products (eggs, milk, yogurt). Vegetarians, vegans and elderly are prone to vitamin B-12 deficiencies.
B 6 - Vital to make neurotransmitters and for myelin formation (which protect nerve connectors called axons). It’s found in cereal grains, legumes, vegetables (carrots, spinach, peas), potatoes, dairy, liver, meat and more.
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