And the ad has some McCain women supporters crying sexism.

Obama has launched a television media blitz in the waning days of the campaign, which included a 30-minute, $3 million infomercial that aired on major networks last night. On top of that, the anti-Palin ad was Obama’s first advertisement critical of the Alaska governor.

In response, McCain’s campaign sent an e-mail blast around, with quotes from a number of female McCain supporters criticizing the ad.

“Enough is enough! Sen. Obama has stooped to a new low in his constant attacks on Gov. Palin,” said July Black, national co-chair for Women for McCain in Virginia. “Barack Obama’s choice has been to attack, demean and ridicule women, first Sen. Clinton and now Gov. Palin. American women do not need any more of Obama’s sexist choices or attacks.”

Missouri Rep. Jo Anne Emerson said: "With each attack, they attempt to dismiss the intelligent, qualified and experienced woman who will soon become our next vice president of the United States."

Democratic National Committee Platform Committee member Prameela Bartholomeusz in California said: "Sen. Obama never spoke up against sexism during the primary season, and is not speaking out against misogyny during this phase of the election season — he is contributing to it. I have no confidence that Sen. Obama will fight for women’s issues if elected. This sets women back decades."

In New York, Amy Siskind, an ambassador for Clinton and co-founder of The New Agenda women’s group: "When Senator Hillary Clinton was demeaned and degraded during the presidential primary, many of us, myself included, vowed ‘never again.’ The treatment of Gov. Palin by both the mainstream media, and now the Obama Campaign, shows that the misogyny fest is alive and well in our country. There has been a complete and utter smear job of our fellow citizen, Sarah Palin, who is only trying to serve her country."

McCain and the Republican National Committee also made their own ads, which said Obama wasn’t ready for the White House. One called him "risky," while another airing in North Carolina shows stormy seas and asks, "What if this storm does get worse?" Another, shown below, says "Barack Obama’s not ready … Yet." Yet?